Colorado bounced back from a blowout loss at Nebraska with a 28-9 win over rival Colorado State last week, but now it will try to avoid falling victim to a letdown spot when it hosts Baylor on Saturday night. The Buffaloes have dominated headlines since the beginning of last season, while the Bears are flying under the radar heading into the Week 4 college football schedule. Colorado is a slight 1.5-point favorite in the Week 4 college football odds, making it one of the most intriguing Week 4 college football spreads.
There are also four ranked vs. ranked matchups this weekend, headlined by No. 6 Tennessee (-7) at No. 15 Oklahoma on Saturday night. The Vols have scored more than 50 points in each of their first three games, while the Sooners got past Houston and Tulane heading into their first ever SEC game. OU opened as the favorite in the lookahead lines, but that spread has swung dramatically in Tennessee’s favor. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!
Now, it has turned its attention to the latest college football odds and Week 4 college football betting lines on the spread, money line and over/under. Head here to see every pick.
Top college football predictions for Week 4
One of the college football picks the model is high on during Week 4: UCLA (+24.5) stays well within the spread at No. 16 LSU in a 3:30 p.m. ET matchup on Saturday. The Tigers are riding an 11-game home winning streak and are coming off a 36-33 road win at South Carolina, but they have not covered the spread in any of their first three games. They have failed to cover in five consecutive September contests and are 3-9 against the spread in their last 12 Week 4 games, making them a team to fade as heavy favorites.
UCLA opened its campaign with a road win at Hawaii before falling to Indiana at home last week. Senior quarterback Ethan Garbers has thrown for 409 yards and a touchdown while rushing for 68 yards, giving LSU another dual-threat quarterback to deal with. The Bruins are 4-1 straight up in their last five games against SEC opponents, and the model has them covering the spread in more than 70% of the latest simulations. See the rest of its Week 4 college football picks here.
Another prediction: Florida State (-2.5) finally wins and covers the spread against California in a 7 p.m. ET kickoff on Saturday. Finding value is all about getting the right number, and Florida State’s brutal start to the season has created a valuable contrarian spot on Saturday night. The Seminoles have certainly been disappointing through their first three games, but they were 17-point home favorites against Boston College just two weeks ago.
Meanwhile, Cal was a 12-point underdog when it traveled to unranked Auburn earlier this month, so this is a drastic adjustment. The Golden Bears are coming off a sloppy performance against a San Diego State team that was playing without its starting quarterback. They committed 12 penalties for 113 yards in that contest, and it will be difficult for them to go on the road and spring an upset with those kinds of undisciplined mistakes. SportsLine’s model has Florida State picking up its first win of the season on Saturday, as the Seminoles are covering the spread in over 60% of simulations. See picks for every other game in Week 4 here.
How to make college football picks for Week 4
The model has also made the call on who wins and covers in every FBS matchup in Week 4, and it’s calling for multiple underdogs to win outright. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which underdogs win outright in Week 4? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.
College football odds for Week 4
See full Week 4 college football picks, odds, predictions here
Thursday, Sept. 19
South Alabama at Appalachian State (-7, 62.5)
Friday, Sept. 20
Stanford at Syracuse (-8.5, 57.5)
Illinois at Nebraska (-8.5, 43.5)
San Jose State at Washington State (-11.5, 55.5)
Saturday, Sept. 21
North Carolina State at Clemson (-20.5, 46.5)
Florida at Mississippi State (+6, 58.5)
Marshall at Ohio State (-39.5, 52.5)
Arkansas at Auburn (-3, 56.5)
USC at Michigan (+5.5, 44.5)
Utah at Oklahoma State (+2.5, 54)
Tennessee at Oklahoma (+7, 57.5)
Louisiana-Monroe at Texas (-44.5, 52.5)
Baylor at Colorado (-1.5, 51)
Kansas State at BYU (+6.5, 48.5)
