Panthers vs. Saints odds, line, spread: Monday Night Football picks, predictions by NFL model on 163-114 roll

bryce young carolina panthers usatsi

The New Orleans Saints (1-0) and Carolina Panthers (0-1) will battle in the first game of a Monday Night Football doubleheader. New Orleans snagged a close 16-15 win over the Tennessee Titans at home to start the 2023 campaign. Meanwhile, the Panthers struggled and endured a 24-10 loss to division foe Atlanta Falcons. Entering Week 2, the Saints were fifth in the league in passing offense (282). Similarly, Carolina was fifth in rushing offense (154).  

Kickoff from Bank of America Stadium in Charlotte is set for 7:15 p.m. ET. New Orleans is a three-point favorite in the Saints vs. Panthers odds according to SportsLine consensus, while the over/under for total points is 39.5. Before locking in any Panthers vs. Saints picks, make sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2023 NFL season on an incredible 163-114 run on top-rated NFL picks that dates back to the 2017 season. It also is on a 17-7 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Panthers vs. Saints 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Saints vs. Panthers:

  • Panthers vs. Saints spread: Saints -3
  • Panthers vs. Saints over/under: 39.5 points
  • Panthers vs. Saints money line: Saints -160, Panthers +138
  • CAR: 9-9 against the spread since the start of the 2022 season 
  • NO: 7-11 ATS since the start of the 2022 season 
  • Panthers vs. Saints picks: See picks at SportsLine
  • Panthers vs. Saints live stream: fubo (try for free)

Why the Saints can cover

The Saints’ defense will make life difficult on rookie quarterback Bryce Young. In the season-opening win over the Titans, they held that group to 181 passing yards. Marshon Lattimore is a shutdown No. 1 cornerback with standout ball skills and coverage ability. Lattimore can get physical and cause pass breakups. In Week 1, Lattimore had two tackles, four pass deflections, and one interception.

New Orleans’ linebacker duo is instinctive. Linebacker Demario Davis is nimble and quick-footed. Davis has strong awareness and led the team in total tackles (10) in Week 1. Linebacker Pete Werner has strong athleticism and sideline-to-sideline speed. Werner gives superb effort and has a nose for the football. He ranks second on the team in total tackles (eight) and had a half-sack last week. See who to back at SportsLine. 

Why the Panthers can cover

Young is making his debut in front of the home crowd. The Alabama product was the No. 1 pick in the 2023 NFL Draft and displayed poise and command in his collegiate career. In the season-opener, Young throw for 146 yards with one touchdown and two interceptions. The Panthers, however, have an effective ground attack that can help take pressure off Young.

Carolina piled up 154 rushing yards in Week 1, which ranks fourth in the NFL. Running back Miles Sanders has impressive lateral quickness and totaled 18 carries for 72 yards in the loss to the Falcons. Running back Chuba Hubbard provides Carolina with a change of pace with his breakaway speed. Last week, he had nine carries for 60 yards and ran for six first downs. See who to back at SportsLine.

How to make Panthers vs. Saints picks

SportsLine’s model is leaning Under the total, projecting 39 combined points. The model also says one side of the spread hits in over 50% of simulations. You can only see the model’s NFL picks and analysis at SportsLine. 

So who wins Saints vs. Panthers on Monday Night Football, and which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the Saints vs. Panthers spread to back, all from the model that has returned more than $7,000 on top-rated NFL picks, and find out.

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